Rapid-onset piperacillin-tazobactam induced thrombocytopenia

J Pharm Pract. 2015 Apr;28(2):204-6. doi: 10.1177/0897190014566302. Epub 2015 Jan 21.


Thrombocytopenia can occur from a variety of etiologies. Drug-induced thrombocytopenia is known to occur with beta-lactam medications, but often in the setting of prolonged use. We describe 2 patients who developed rapid-onset thrombocytopenia from piperacillin/tazobactam. Other causes of immediate thrombocytopenia were excluded. These cases describe a rare presentation of rapid-onset thrombocytopenia in a commonly used medication.

Keywords: drug information; internal medicine.

Publication types

  • Case Reports

MeSH terms

  • Anti-Bacterial Agents / adverse effects*
  • Female
  • Humans
  • Middle Aged
  • Penicillanic Acid / adverse effects
  • Penicillanic Acid / analogs & derivatives*
  • Piperacillin / adverse effects*
  • Tazobactam
  • Thrombocytopenia / chemically induced*


  • Anti-Bacterial Agents
  • Penicillanic Acid
  • Tazobactam
  • Piperacillin