Comparison of the effects of famotidine and ranitidine on gastric secretion in patients undergoing elective surgery

Anaesthesia. 1989 Mar;44(3):212-5. doi: 10.1111/j.1365-2044.1989.tb11225.x.


A randomised double-blind comparison of oral famotidine and ranitidine given 2 hours before induction, on gastric secretion (volume and pH) was carried out on 93 patients undergoing elective surgery. Gastric contents were aspirated immediately after tracheal intubation. Famotidine significantly reduced the gastric volume, compared with the other groups, including ranitidine. Both famotidine and ranitidine significantly elevated gastric pH towards neutral, compared with the other groups. There was no significant difference between ranitidine and famotidine in respect of the pH. The patients premedicated with famotidine and ranitidine were well protected against Mendelson's syndrome, whereas 38% of patients from the other groups remained at risk.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthesia, General
  • Clinical Trials as Topic
  • Double-Blind Method
  • Famotidine
  • Female
  • Gastric Juice / metabolism
  • Histamine H2 Antagonists / therapeutic use*
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Middle Aged
  • Pneumonia, Aspiration / prevention & control*
  • Postoperative Complications / prevention & control*
  • Premedication*
  • Random Allocation
  • Ranitidine / therapeutic use*
  • Thiazoles / therapeutic use*


  • Histamine H2 Antagonists
  • Thiazoles
  • Famotidine
  • Ranitidine