Clival dedifferentiated chordoma: a case report

Anal Quant Cytopathol Histpathol. 2014 Dec;36(6):330-4.


Background: Chordoma is a rare, slowly growing tumor arising from notochordal rests and occurring in several anatomical locations with different clinical patterns of presentation. Dedifferentiation or sarcomatous transformation in a chordoma is a known but rarely recorded event.

Case: We report the case of a 58-year-old man diagnosed with chordoma of the clivus who, over the course of 5 years, showed histological and immunohistochemical evidence of progressive dedifferentiation in the tumor.

Conclusion: Sarcomatous transformation in chordomas is seen less frequently in the clival region. A high degree of suspicion and extensive sampling are essential for diagnosis, especially in recurrent tumors.

Publication types

  • Case Reports

MeSH terms

  • Brain Neoplasms / diagnostic imaging*
  • Brain Neoplasms / pathology
  • Cell Dedifferentiation*
  • Chordoma / diagnostic imaging*
  • Chordoma / pathology
  • Humans
  • Male
  • Middle Aged
  • Radiography