Beyond microbial community composition: functional activities of the oral microbiome in health and disease

Ana E Duran-Pinedo; Jorge Frias-Lopez

doi:10.1016/j.micinf.2015.03.014

Beyond microbial community composition: functional activities of the oral microbiome in health and disease

Microbes Infect. 2015 Jul;17(7):505-16. doi: 10.1016/j.micinf.2015.03.014. Epub 2015 Apr 7.

Authors

Ana E Duran-Pinedo¹, Jorge Frias-Lopez²

Affiliations

¹ Department of Microbiology, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA.
² Department of Microbiology, The Forsyth Institute, 245 First Street, Cambridge, MA 02142, USA; Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA. Electronic address: jfriaslopez@forsyth.org.

Abstract

The oral microbiome plays a relevant role in the health status of the host and is a key element in a variety of oral and non-oral diseases. Despite advances in our knowledge of changes in microbial composition associated with different health conditions the functional aspects of the oral microbiome that lead to dysbiosis remain for the most part unknown. In this review, we discuss the progress made towards understanding the functional role of the oral microbiome in health and disease and how novel technologies are expanding our knowledge on this subject.

Keywords: Caries; Dysbiosis; Microbiome; Omics; Oral; Periododontitis.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Dental Caries / etiology*
Dental Caries / pathology
Gastrointestinal Microbiome / immunology*
Health Status*
Host-Pathogen Interactions / immunology*
Humans
Metagenome
Oral Health*

Abstract

Publication types

MeSH terms

Grants and funding