ROS1 rearranged non-small cell lung cancer brain metastases respond to low dose radiotherapy

J Clin Neurosci. 2015 Dec;22(12):1978-9. doi: 10.1016/j.jocn.2015.04.009. Epub 2015 Jul 7.


We present a young woman with ROS1 gene rearranged non-small cell lung cancer (NSCLC) with brain metastases. ROS is a proto-oncogene tyrosine protein kinase. The patient received a partial course of whole brain radiation therapy and experienced a sustained partial response in the brain. We hypothesize that ROS1 rearranged NSCLC brain metastases may be particularly sensitive to radiation therapy.

Keywords: Brain metastases; Crizotinib; Non-small cell lung cancer; ROS1; Radiotherapy.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / radiotherapy*
  • Brain Neoplasms / secondary
  • Carcinoma, Non-Small-Cell Lung / genetics
  • Carcinoma, Non-Small-Cell Lung / radiotherapy*
  • Carcinoma, Non-Small-Cell Lung / secondary
  • Female
  • Gene Rearrangement
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology*
  • Lung Neoplasms / radiotherapy
  • Protein-Tyrosine Kinases / genetics*
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins / genetics*


  • MAS1 protein, human
  • Proto-Oncogene Mas
  • Proto-Oncogene Proteins
  • Protein-Tyrosine Kinases
  • ROS1 protein, human