Obesity, Exercise, Obstructive Sleep Apnea, and Modifiable Atherosclerotic Cardiovascular Disease Risk Factors in Atrial Fibrillation

J Am Coll Cardiol. 2015 Dec 29;66(25):2899-2906. doi: 10.1016/j.jacc.2015.10.047.


Classically, the 3 pillars of atrial fibrillation (AF) management have included anticoagulation for prevention of thromboembolism, rhythm control, and rate control. In both prevention and management of AF, a growing body of evidence supports an increased role for comprehensive cardiac risk factor modification (RFM), herein defined as management of traditional modifiable cardiac risk factors, weight loss, and exercise. In this narrative review, we summarize the evidence demonstrating the importance of each facet of RFM in AF prevention and therapy. Additionally, we review emerging data on the importance of weight loss and cardiovascular exercise in prevention and management of AF.

Keywords: diabetes; hyperlipidemia; hypertension.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Atherosclerosis / complications*
  • Atherosclerosis / physiopathology
  • Atrial Fibrillation / etiology*
  • Atrial Fibrillation / physiopathology
  • Exercise / physiology*
  • Humans
  • Obesity / complications*
  • Obesity / physiopathology
  • Risk Factors
  • Sleep Apnea, Obstructive / complications*
  • Sleep Apnea, Obstructive / physiopathology