Mechanisms of Disease of Eosinophilic Esophagitis

Annu Rev Pathol. 2016 May 23:11:365-93. doi: 10.1146/annurev-pathol-012615-044241. Epub 2016 Feb 24.


Eosinophilic esophagitis (EoE) is a recently recognized inflammatory disease of the esophagus with clinical symptoms derived from esophageal dysfunction. The etiology of EoE is now being elucidated, and food hypersensitivity is emerging as the central cornerstone of disease pathogenesis. Herein, we present a thorough picture of the current clinical, pathologic, and molecular understanding of the disease with a focus on disease mechanisms.

Keywords: atopy; barrier dysfunction; eosinophilic esophagitis; epithelial inflammation; fibrosis.

Publication types

  • Review

MeSH terms

  • Eosinophilic Esophagitis / etiology
  • Eosinophilic Esophagitis / physiopathology*
  • Food Hypersensitivity / complications
  • Humans