Structure of a novel 13 nm dodecahedral nanocage assembled from a redesigned bacterial microcompartment shell protein

Chem Commun (Camb). 2016 Apr 11;52(28):5041-4. doi: 10.1039/c6cc00851h. Epub 2016 Mar 18.


We report the crystal structure of a novel 60-subunit dodecahedral cage that results from self-assembly of a re-engineered version of a natural protein (PduA) from the Pdu microcompartment shell. Biophysical data illustrate the dependence of assembly on solution conditions, opening up new applications in microcompartment studies and nanotechnology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Bacterial Proteins / chemistry*
  • Molecular Structure
  • Nanostructures / chemistry*
  • Nanotechnology
  • Protein Engineering
  • Salmonella typhimurium / chemistry*


  • Bacterial Proteins