Strategies to target non-T-cell HIV reservoirs

Curr Opin HIV AIDS. 2016 Jul;11(4):376-82. doi: 10.1097/COH.0000000000000283.


Purpose of review: A central question for the HIV cure field is to determine new ways to target clinically relevant, latently and actively replicating HIV-infected cells beyond resting memory CD4 T cells, particularly in anatomical areas of low drug penetrability.

Recent findings: HIV eradication strategies being positioned for targeting HIV for extinction in the CD4 T-cell compartment may also show promise in non-CD4 T-cells reservoirs. Furthermore, several exciting novel therapeutic approaches specifically focused on HIV clearance from non-CD4 T-cell populations are being developed.

Summary: Although reservoir validity in these non-CD4 T cells continues to remain debated, this review will highlight recent advances and make an argument as to their clinical relevancy as we progress towards an HIV cure.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Biomedical Research / trends
  • Drug Therapy / methods*
  • HIV / physiology*
  • HIV Infections / therapy*
  • HIV Infections / virology*
  • Humans
  • Immunotherapy / methods*
  • Virus Latency*
  • Virus Replication*