Removal from liver transplantation list of a hepatitis C virus-HIV co-infected patient after successful treatment with sofosbuvir and daclatasvir

Transpl Infect Dis. 2016 Jun;18(3):442-445. doi: 10.1111/tid.12538. Epub 2016 Jun 9.

Abstract

We present a human immunodeficiency virus-infected patient with severe decompensated hepatitis C virus-related cirrhosis awaiting liver transplantation (LT) who received a 24-week course of interferon/ribavirin-free antiviral treatment with sofosbuvir and daclatasvir on a compassionate basis. Rapid viral suppression was associated with progressive improvement of his liver function tests. The patient achieved a sustained virological response and concomitant clinical improvement, which prompted removal from the LT list 12 weeks after the end of treatment.

Keywords: daclatasvir; hepatitis C virus; human immunodeficiency virus; sofosbuvir; transplant.

Publication types

  • Case Reports