In Vivo Visualization of Prostate-Specific Membrane Antigen in Adenoid Cystic Carcinoma of the Salivary Gland

Clin Nucl Med. 2016 Jun;41(6):476-7. doi: 10.1097/RLU.0000000000001220.


As the prostate-specific membrane antigen (PSMA) is overexpressed in the neovasculature of several malignancies, it might serve as a target in oncology. Ga-PSMA PET/CT and PET/MRI were performed in a female who developed pulmonary metastases from an adenoid cystic carcinoma of the right sublingual salivary gland after incomplete resection of the primary tumor and radiotherapy. Uptake of Ga-PSMA in tumors was observed, indicating PSMA expression. Moreover, a new cerebral metastasis was detected. Potentially, Ga-PSMA PET might be used for noninvasive assessment of adenoid cystic carcinoma to evaluate whether patients apply for PSMA-based radiotherapy when no further treatment options are available.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma, Adenoid Cystic / diagnostic imaging*
  • Carcinoma, Adenoid Cystic / secondary
  • Edetic Acid / analogs & derivatives
  • Female
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / secondary
  • Magnetic Resonance Imaging
  • Middle Aged
  • Multimodal Imaging
  • Oligopeptides
  • Positron Emission Tomography Computed Tomography
  • Positron-Emission Tomography
  • Sublingual Gland Neoplasms / diagnostic imaging*
  • Sublingual Gland Neoplasms / pathology


  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • gallium 68 PSMA-11
  • Edetic Acid