Azathioprine induced hepatic veno-occlusive disease in rheumatoid arthritis

Ann Rheum Dis. 1989 Apr;48(4):342-6. doi: 10.1136/ard.48.4.342.


A patient with rheumatoid arthritis developed hepatic veno-occlusive disease following the use of azathioprine. Although azathioprine induced veno-occlusive disease is suspected to occur more frequently in patients with autoimmune dysfunction, it has not previously been reported as a complication of treatment in rheumatoid arthritis. The mechanism responsible for this condition remains unknown.

Publication types

  • Case Reports

MeSH terms

  • Arthritis, Rheumatoid / complications*
  • Arthritis, Rheumatoid / drug therapy
  • Arthritis, Rheumatoid / pathology
  • Azathioprine / adverse effects*
  • Hepatic Veno-Occlusive Disease / chemically induced*
  • Hepatic Veno-Occlusive Disease / pathology
  • Humans
  • Liver / pathology
  • Male
  • Middle Aged


  • Azathioprine