Characteristics of Sleep Disturbances in Patients with Gastroesophageal Reflux Disease

Intern Med. 2016;55(12):1511-7. doi: 10.2169/internalmedicine.55.5454. Epub 2016 Jun 15.


Objective Gastroesophageal reflux disease (GERD) is strongly associated with sleep disturbances; however, the detailed differences in the characteristics of sleep disturbances between GERD and non-GERD patients are unknown. The aim of the present study was to analyze the clinical characteristics as well as health-related quality of life in GERD and non-GERD patients with sleep disturbances. Methods Three hundred and fifty patients, including 124 patients with GERD and 226 patients without GERD, completed a self-administered questionnaire that evaluated clinical information. The Pittsburg Sleep Quality Index (PSQI), Hospital Anxiety and Depression Scale (HADS), Insomnia Severity Index (ISI), Epworth Sleepiness Scale (ESS) and 8-item Short-Form Health Survey (SF-8) were also used. Sleep disturbance was considered to be present if the PSQI was >5.5. Results The prevalence of sleep disturbances was significantly higher in the GERD patients (66/124, 53.9%) than in the non-GERD patients (89/226, 39.3%). Depression and anxiety were significantly more common in the subjects with sleep disturbances than in those without sleep disturbances, although there were no differences between the GERD and non-GERD patients. Among the subjects with sleep disturbances, daytime sleepiness was more common in the GERD patients than in the non-GERD patients. The subjects with sleep disturbances had a poorer health-related quality of life. The physical components of quality of life were impaired, particularly in the GERD patients with sleep disturbances. Conclusion GERD patients with sleep disturbances commonly experience daytime sleepiness and an impaired health-related quality of life, especially in terms of physical components.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Anxiety / epidemiology
  • Anxiety / etiology
  • Cross-Sectional Studies
  • Depression / epidemiology
  • Depression / etiology
  • Female
  • Gastroesophageal Reflux / complications*
  • Gastroesophageal Reflux / epidemiology
  • Gastroesophageal Reflux / psychology
  • Gastroesophageal Reflux / rehabilitation
  • Humans
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Psychiatric Status Rating Scales
  • Psychometrics
  • Quality of Life
  • Sleep Stages
  • Sleep Wake Disorders / epidemiology
  • Sleep Wake Disorders / etiology*
  • Sleep Wake Disorders / psychology
  • Sleep Wake Disorders / rehabilitation
  • Surveys and Questionnaires