External validation of clinical prediction models using big datasets from e-health records or IPD meta-analysis: opportunities and challenges

BMJ. 2016 Jun 22;353:i3140. doi: 10.1136/bmj.i3140.

Abstract

Access to big datasets from e-health records and individual participant data (IPD) meta-analysis is signalling a new advent of external validation studies for clinical prediction models. In this article, the authors illustrate novel opportunities for external validation in big, combined datasets, while drawing attention to methodological challenges and reporting issues.

MeSH terms

  • Datasets as Topic
  • Decision Support Techniques*
  • Electronic Health Records
  • Humans
  • Meta-Analysis as Topic
  • Models, Statistical*
  • Registries
  • Risk Assessment / methods
  • Validation Studies as Topic*