Animal Studies and the Mechanism of Myopia-Protection by Light?

Optom Vis Sci. 2016 Sep;93(9):1052-4. doi: 10.1097/OPX.0000000000000978.


Epidemiological studies have demonstrated that spending time outdoors during your childhood is protective against the development of myopia. It has been hypothesized that this protective effect is associated with light-induced increases in retinal dopamine levels, a critical neuromodulator that has long been postulated to be involved in the regulation of ocular growth. This paper, along with the paper entitled "What do animal studies tell us about the mechanism of myopia-protection by light?" discusses the evidence provided by animal models for this hypothesis.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Models, Animal
  • Light / adverse effects*
  • Myopia / etiology
  • Myopia / prevention & control*
  • Refraction, Ocular / physiology
  • Refraction, Ocular / radiation effects*