Systematic evaluation on the effectiveness of conjugated linoleic acid in human health

Crit Rev Food Sci Nutr. 2017 Jan 2;57(1):1-7. doi: 10.1080/10408398.2012.716800.


The term CLA (conjugated linoleic acid) corresponds to a mixture of positional and geometric isomers of linoleic acid. Two of these isomers (9c, 11t and 10t, 12c) have biological activity. The milk and dairy products are the most abundant source of conjugated linoleic acid, which refers to a group of positional and geometric isomers of CLA (CLA 18:2 cis-9, cis-12). The following research aims to approach aspects regarding the CLA, as well as its relationship with diseases. Conjugated linoleic acids have been studied for their beneficial effects in the prevention and treatment of many diseases, including obesity, cancer, diabetes, and cardiovascular diseases. Scientific information put together the physiological properties of CLA, which serves as inputs to claim their potential as functional ingredients to be used in the prevention and control of several chronic metabolic disorders.

Keywords: Conjugated linoleic acid; benefit; dairy; health.

Publication types

  • Review

MeSH terms

  • Animals
  • Anticarcinogenic Agents / chemistry
  • Anticarcinogenic Agents / metabolism
  • Anticarcinogenic Agents / therapeutic use
  • Body Composition
  • Chronic Disease / prevention & control*
  • Dairy Products*
  • Dietary Supplements*
  • Evidence-Based Medicine*
  • Functional Food*
  • Humans
  • Insulin Resistance
  • Linoleic Acids, Conjugated / chemistry
  • Linoleic Acids, Conjugated / metabolism
  • Linoleic Acids, Conjugated / therapeutic use*
  • Lipid Metabolism
  • Molecular Structure
  • Stereoisomerism


  • Anticarcinogenic Agents
  • Linoleic Acids, Conjugated