Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue

Oliwia Rysnik; Kirsty McHugh; Leonie van Duivenvoorde; Melissa van Tok; Joel Taurog; Simon Kollnberger; Dominique Baeten; Paul Bowness

doi:10.1016/j.dib.2016.08.046

Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue

Data Brief. 2016 Aug 28:9:100-11. doi: 10.1016/j.dib.2016.08.046. eCollection 2016 Dec.

Authors

Oliwia Rysnik¹, Kirsty McHugh¹, Leonie van Duivenvoorde², Melissa van Tok², Joel Taurog³, Simon Kollnberger⁴, Dominique Baeten², Paul Bowness¹

Affiliations

¹ Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science, University of Oxford, Oxford, UK.
² Amsterdam Rheumatology and Immunology Center, Department of Clinical Immunology and Rheumatology, Department of Experimental Immunology Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
³ Department of Internal Medicine, Rheumatic Diseases Division, University of Texas Southwestern Medical Center, Dallas, USA.
⁴ Cardiff Institute of Infection & Immunity, Henry Wellcome Building, Heath Park, Cardiff CF14 4XN, UK.

Abstract

Data is presented showing expression of non-conventional (NC) heavy chain forms of B27 in synovial tissues from SpA patients. Data is presented showing the expression patterns of NC-B27 in joint, gastrointestinal and lymphoid tissues from B27 transgenic (TG(1)) rats with M. tuberculosis-induced SpA. Expression of NC-B27 was determined by immunohistochemistry and flow cytometry using HC10 and HD6 antibodies. These data are the extension of the data presented and discussed in "Non-conventional forms of HLA-B27 are expressed in Spondyloarthritis joints and gut tissue" (O. Rysnik, K. McHugh, L. M. van Duivenvoorde, M. N. van Tok, G. Guggino, J. D. Taurog, S. Kollnberger, F. Ciccia, D. L. Baeten, P. Bowness, 2016) [1].

Keywords: HLA class I free-heavy chains; HLA-B27; HLA-B27 transgenic rat model; Spondyloarthropathies.

Grants and funding

19611/VAC_/Versus Arthritis/United Kingdom