Searching for better animal models of BPD: a perspective

Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L924-L927. doi: 10.1152/ajplung.00355.2016. Epub 2016 Sep 23.


There have been many efforts to develop good animal models of bronchopulmonary dysplasia (BPD) to better understand the pathophysiology and mechanisms underlying development of BPD as well as to test potential strategies for its prevention and treatment. This Perspectives summarizes the features of common animal models of BPD and the strengths and limitations of such models. Potential optimal approaches to development of animal models are indicated, with the underlying concepts that require emphasis.

Keywords: animal models; bronchopulmonary dysplasia; diseases; infant; lung development; lung injury; premature.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Bronchopulmonary Dysplasia / pathology*
  • Bronchopulmonary Dysplasia / therapy
  • Disease Models, Animal*
  • Humans
  • Infant, Newborn
  • Lung / embryology
  • Lung / pathology