Circadian regulation of auditory function

Hear Res. 2017 Apr:347:47-55. doi: 10.1016/j.heares.2016.08.018. Epub 2016 Sep 23.


The circadian system integrates environmental cues to regulate physiological functions in a temporal fashion. The suprachiasmatic nucleus, located in the hypothalamus, is the master clock that synchronizes central and peripheral organ clocks to orchestrate physiological functions. Recently, molecular clock machinery has been identified in the cochlea unravelling the potential involvement in the circadian regulation of auditory functions. Here, we present background information on the circadian system and review the recent findings that introduce circadian rhythms to the auditory field. Understanding the mechanisms by which circadian rhythms regulate auditory function will provide fundamental knowledge on the signalling networks that control vulnerability and resilience to auditory insults.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acoustic Stimulation
  • Animals
  • Auditory Pathways / metabolism
  • Auditory Pathways / physiology*
  • Auditory Perception*
  • Circadian Clocks*
  • Circadian Rhythm Signaling Peptides and Proteins / metabolism
  • Circadian Rhythm*
  • Cochlea / metabolism
  • Cochlea / physiology*
  • Cues
  • Hearing*
  • Humans
  • Signal Transduction


  • Circadian Rhythm Signaling Peptides and Proteins