Changes in brain gene expression shared by scrapie and Alzheimer disease

Proc Natl Acad Sci U S A. 1989 Sep;86(18):7260-4. doi: 10.1073/pnas.86.18.7260.

Abstract

We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippocampus from patients with Alzheimer disease and Pick disease, whereas transferrin RNA is not strongly modulated in these conditions. Expression of two previously identified scrapie-modulated genes, encoding glial fibrillary acidic protein and metallothionein, is also increased in both of these neurodegenerative diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / genetics*
  • Alzheimer Disease / metabolism
  • Animals
  • Base Sequence
  • Brain / metabolism*
  • Clusterin
  • Cricetinae
  • Genes*
  • Glial Fibrillary Acidic Protein / genetics*
  • Glycoproteins / genetics*
  • Metallothionein / genetics*
  • Molecular Chaperones*
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • RNA, Messenger / genetics
  • Rats
  • Scrapie / genetics*
  • Scrapie / metabolism
  • Sequence Homology, Nucleic Acid
  • Transcription, Genetic
  • Transferrin / genetics*

Substances

  • Clusterin
  • Glial Fibrillary Acidic Protein
  • Glycoproteins
  • Molecular Chaperones
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Transferrin
  • Metallothionein

Associated data

  • GENBANK/M26637
  • GENBANK/M26638
  • GENBANK/M26639
  • GENBANK/M26640
  • GENBANK/M26641
  • GENBANK/M26642