The promoter regions of the T-cell receptor V9 gamma (TRGV9) and V2 delta (TRDV2) genes display short direct repeats but no TATA box

FEBS Lett. 1989 Oct 9;256(1-2):185-91. doi: 10.1016/0014-5793(89)81745-4.

Abstract

T lymphocytes expressing the T-cell gamma delta receptor have been shown to express preferentially the T-cell receptor V9 gamma (TRGV9) gene, in association with the T-cell receptor V2 delta (TRDV2) gene. In this paper, we report that the promoter regions of the TRDV2 and TRGV9 genes, which are preferentially expressed early in T-cell differentiation, display short direct repeats but no TATA box, in contrast to the V gamma genes belonging to subgroup I. The TCCTCAGT octanucleotide found 100 pb upstream of the ATG of the HD-Mar V alpha transcript, a TCR V alpha gene without a TATA box, is observed upstream of TRDV2 but not TRGV9. Of interest is the presence of a characteristic decanucleotide AGGTGGT(T)GAG in the promoter regions of both the TRDV2 and TRGV9 genes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA / isolation & purification
  • Genes*
  • Humans
  • Molecular Sequence Data
  • Oligonucleotides / isolation & purification
  • Promoter Regions, Genetic*
  • Receptors, Antigen, T-Cell / genetics*
  • Repetitive Sequences, Nucleic Acid*
  • Transcription, Genetic*

Substances

  • Oligonucleotides
  • Receptors, Antigen, T-Cell
  • DNA

Associated data

  • GENBANK/X15269
  • GENBANK/X15270
  • GENBANK/X15271
  • GENBANK/X15272
  • GENBANK/X15273
  • GENBANK/X15274
  • GENBANK/X15275