The GroinPain Trial: A Randomized Controlled Trial of Injection Therapy Versus Neurectomy for Postherniorraphy Inguinal Neuralgia

Ann Surg. 2018 May;267(5):841-845. doi: 10.1097/SLA.0000000000002274.

Abstract

Objective: This study compares tender point infiltration (TPI) and a tailored neurectomy as the preferred treatment for chronic inguinodynia after inguinal herniorraphy.

Background: Some 11% of patients develop chronic discomfort after open inguinal herniorraphy. Both TPI and neurectomy have been suggested as treatment options, but evidence is conflicting.

Methods: Patients with chronic neuropathic pain after primary Lichtenstein repair and >50% pain reduction after a diagnostic TPI were randomized for repeated TPI (combined Lidocaine/corticosteroids /hyaluronic acid injection) or for a neurectomy. Primary outcome was success (>50% pain reduction using Visual Analog Scale, VAS) after 6 months. Cross-over to neurectomy was offered if TPI was unsuccessful.

Results: A total of 54 patients were randomized in a single center between January 2006 and October 2013. Baseline VAS was similar (TPI: 55, range 10-98 vs neurectomy: 53, range 18-82, P = 0.86). TPI was successful in 22% (n = 6), but a neurectomy was successful in 71% (n = 17, P = 0.001). After unsuccessful TPI, 19 patients crossed over to neurectomy and their median VAS score dropped from 60 to 14 (P = 0.001). No major complications after surgery were reported. Two-thirds of patients on worker's compensation returned to work.

Conclusion: A tailored neurectomy is 3 times more effective than tender point infiltration in chronic inguinodynia after anterior inguinal hernia mesh repair. A step up treatment stratagem starting with tender point infiltration followed by a tailored neurectomy is advised.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthetics, Local / administration & dosage
  • Denervation / methods*
  • Drug Combinations
  • Female
  • Glucocorticoids / administration & dosage*
  • Groin
  • Hernia, Inguinal / surgery*
  • Herniorrhaphy / adverse effects*
  • Humans
  • Hyaluronic Acid / administration & dosage*
  • Inguinal Canal / innervation
  • Injections
  • Lidocaine / administration & dosage*
  • Lumbosacral Plexus / surgery
  • Male
  • Middle Aged
  • Neuralgia / diagnosis
  • Neuralgia / etiology
  • Neuralgia / therapy*
  • Pain Measurement
  • Pain, Postoperative / diagnosis
  • Pain, Postoperative / etiology
  • Pain, Postoperative / therapy
  • Treatment Outcome

Substances

  • Adjuvants, Immunologic
  • Anesthetics, Local
  • Drug Combinations
  • Glucocorticoids
  • Hyaluronic Acid
  • Lidocaine