Clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater

BMC Gastroenterol. 2017 May 31;17(1):70. doi: 10.1186/s12876-017-0630-9.


Background: The study aims to investigate the clinicopathological features and surgical outcomes of neuroendocrine tumors of ampulla of Vater (NETAoVs) patients who underwent pancreaticoduodenectomy.

Methods: From January 2007 to December 2014, 45 patients underwent pancreaticoduodenectomy for malignant disease of the ampulla of Vater in our institution. Of those, 5 patients were diagnosed as neuroendocrine tumors. The data included age, sex, presenting symptoms, preoperative imaging, preoperative type of biopsy results, type of operation, pathologic findings and survival status.

Results: The patient's mean age was 55.2 ± 9.7 years. Endoscopic ultrasound guided biopsy was performed in 4 patients and gastroduodenoscopic biopsy was performed in one patient. All showed neuroendocrine tumor without mitosis. Mean tumor size was 1.9 ± 0.56 cm (range, 1.2-2.0 cm). Lymph node metastases were detected in two patients. All patients were synaptophysin-positive. Median periods of follow-up were 45 months (range, 43-78 months). Recurrence after operation occurred in two patients. 4 patients were alive at the last follow-up.

Conclusions: Radical resection for NETAoVs can provide the information of status of lymph node metastasis after surgery. However, correlation between lymph node metastasis and overall survival is uncertain to date.

Keywords: Ampulla of Vater; Neoplasms; Neuroendocrine tumors; Pancreaticoduodenectomy; Treatment outcome.

MeSH terms

  • Aged
  • Ampulla of Vater / pathology*
  • Ampulla of Vater / surgery*
  • Biopsy
  • Common Bile Duct Neoplasms / mortality
  • Common Bile Duct Neoplasms / pathology*
  • Common Bile Duct Neoplasms / surgery*
  • Female
  • Humans
  • Liver Neoplasms / secondary
  • Lymph Node Excision
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Neuroendocrine Tumors / mortality
  • Neuroendocrine Tumors / pathology*
  • Neuroendocrine Tumors / surgery*
  • Pancreaticoduodenectomy
  • Treatment Outcome