Cost-effectiveness analysis of anidulafungin vs fluconazole for the treatment of invasive candidiasis (IC) in Turkey

Mycoses. 2017 Nov;60(11):714-722. doi: 10.1111/myc.12651. Epub 2017 Jul 12.


Anidulafungin has been shown to be non-inferior to, and possibly more efficacious, than fluconazole in treating patients with invasive candidiasis (IC). This study aimed to determine the cost-effectiveness of anidulafungin vs fluconazole for treatment of IC in the Turkish setting. A decision analytic model was constructed to depict downstream economic consequences of using anidulafungin or fluconazole for treatment of IC in the Turkish hospitals. Transition probabilities (ie treatment success, observed or indeterminate treatment failures) were obtained from a published randomised clinical trial. Cost inputs were from the latest Turkish resources. Data not available in the literature were estimated by expert panels. Sensitivity analyses were performed to assess the robustness of the model outcome. While anidulafungin [TL 17 171 (USD 4589)] incurred a higher total cost than fluconazole [TL 8233 (USD 2200) per treated patient, treatment with anidulafungin was estimated to save an additional 0.58 life-years, with an incremental cost-effectiveness ratio of TL 15 410 (USD 4118) per life-years saved. Drug acquisition cost and hospitalisation were the main cost drivers for anidulafungin and fluconazole arms respectively. The model findings were robust over a wide range of input variables except for anidulafungin drug cost. Anidulafungin appears to be a cost-effective therapy in treating IC from the Turkish hospital perspective.

Keywords: Candida spp.; antifungals; modelling.

MeSH terms

  • Anidulafungin
  • Antifungal Agents / economics
  • Antifungal Agents / therapeutic use*
  • Candidiasis, Invasive / drug therapy*
  • Candidiasis, Invasive / microbiology
  • Cost-Benefit Analysis
  • Decision Support Techniques
  • Double-Blind Method
  • Echinocandins / economics
  • Echinocandins / therapeutic use*
  • Fluconazole / economics
  • Fluconazole / therapeutic use*
  • Humans
  • Randomized Controlled Trials as Topic
  • Treatment Failure
  • Treatment Outcome
  • Turkey


  • Antifungal Agents
  • Echinocandins
  • Fluconazole
  • Anidulafungin