We present a case of a female patient who had a clinically suspected advanced urothelial carcinoma of the urethra. Histopathological examination surprisingly revealed a malignant tumor with morphological and immunohistochemical features of prostate cancer, leading to the diagnosis of the extremely rare entity of Skene's gland adenocarcinoma.
Keywords: Primary specific antigen; Primary urethral adenocarcinoma; Prostate carcinoma; Salivary duct carcinoma; Skene’s gland adenocarcinoma.