Tuberculosis, granulomatosis with polyangiitis, or both? A case report

Arch Soc Esp Oftalmol (Engl Ed). 2018 Feb;93(2):101-104. doi: 10.1016/j.oftal.2017.06.013. Epub 2017 Jul 27.
[Article in English, Spanish]


Introduction: Tuberculosis (TB) is a chronic granulomatose infection, and granulomatosis with polyangiitis (GP) is a small vessel vasculitis, both of which affect the lungs. The combination of these diseases is rare. Both have similar clinical features, making the differential diagnosis difficult.

Case report: It concerns a 37 year-old female undergoing treatment for pulmonary TB, who presented with left ocular proptosis, eyelid and conjunctival edema and erythema. Orbital biopsy revealed GP. C-Anti-neutrophil cytoplasmic antibodies were elevated. The patient responded well to immunosuppressive treatment.

Conclusion: TB and GP can associate. Diagnosis should include not only C-anti-neutrophil cytoplasmic antibodies, but also a biopsy, in order to select the appropriate treatment.

Keywords: Anti-neutrophil cytoplasmic antibodies; Anticuerpos anticitoplasma de neutrófilos; Granulomatosis con poliangeítis; Granulomatosis with polyangiitis; Proptosis; Tuberculosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Eye Diseases / complications*
  • Eye Diseases / diagnosis
  • Female
  • Granulomatosis with Polyangiitis / complications*
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Tuberculosis, Pulmonary / complications*
  • Tuberculosis, Pulmonary / diagnosis