Inherited homeotic midfacial malformations in Burmese cats

J Craniofac Genet Dev Biol Suppl. 1986:2:249-66.


During the past three decades, Burmese cats have been selected for a shorter muzzle and a more rounded face. Recently there arose a line of these animals that consistently exhibit such a brachycephalic appearance; unfortunately, approximately 25% of these kittens are born with a neonatal lethal midfacial malformation. The abnormality is characterized by agenesis of all derivatives of the medial nasal prominence; lateral duplication of most derivatives of the maxillary process; including the canine teeth and whiskers fields; telencephalic meningoencephalocele; and secondary ocular degeneration. The anatomy, embryology, and pattern of inheritance of this unique midfacial malformation are described.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Abnormalities, Multiple / genetics
  • Abnormalities, Multiple / veterinary*
  • Animals
  • Cat Diseases / genetics*
  • Cats
  • Facial Bones / abnormalities*
  • Facial Bones / anatomy & histology
  • Facial Bones / embryology
  • Fetus
  • Genes, Homeobox*
  • Myanmar