Human liver flukes

Lancet Gastroenterol Hepatol. 2017 Sep;2(9):680-689. doi: 10.1016/S2468-1253(17)30111-5.


Liver fluke infections occur in people worldwide. In some low-income regions, a combination of ecological, agricultural, and culinary factors leads to a very high prevalence of infection but, in higher-income regions, infections are uncommon. Infection is associated with substantial morbidity and several liver fluke species are recognised as biological carcinogens. Here, we review the epidemiology, clinical significance, and diagnostic and treatment strategies of human infection with these pathogens.

Publication types

  • Review

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use
  • Choriocarcinoma / complications
  • Choriocarcinoma / parasitology
  • Endemic Diseases
  • Fascioliasis / complications
  • Fascioliasis / diagnosis*
  • Fascioliasis / drug therapy*
  • Fascioliasis / epidemiology
  • Humans
  • Liver Neoplasms / complications
  • Liver Neoplasms / parasitology
  • Poverty
  • Prevalence


  • Anthelmintics