[Sequential development of vitamin D metabolites under isoniazid and rifampicin therapy]

Arch Fr Pediatr. 1988 Feb;45(2):145-8.
[Article in French]


A sequential study of 25-hydroxy vitamin D (25-OH-D), 1.25 dihydroxy vitamin D [1.25 (OH)2-D], PTH, alkaline phosphatase and gammaglutamyl transpeptidase (gamma GT) was undertaken in a series of 46 children with asymptomatic tuberculosis treated by isoniazid (INH) alone or associated with rifampin (RMP). These parameters were measured before treatment, 1 month, 3 months after the onset and at the end of treatment (6 months). In order to reduce the influence of the time of the year on the 25-OH-D levels, 22 patients were selected for whom the whole treatment took place between October and May of the following year. In this group, 13 children were treated by INH and RMP, 9 by INH alone. A statistically significant decrease in 25-OH-D levels could be demonstrated after 3 months of treatment in 13 patients under INH and RMP as well as a significant increase in alkaline phosphatase and gamma GT levels. In 9 patients given INH alone, 1.25 (OH)2-D levels decreased after 3 months without significant changes in 25-OH-D, alkaline phosphatase or gamma GT levels. These results emphasize the need for regular biochemical supervision, even if no sign of rickets is observed in these patients.

Publication types

  • English Abstract

MeSH terms

  • Adolescent
  • Adult
  • Alkaline Phosphatase / blood
  • Calcitriol / blood
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Hydroxycholecalciferols / blood*
  • Isoniazid / pharmacology*
  • Isoniazid / therapeutic use
  • Male
  • Parathyroid Hormone / blood
  • Rifampin / pharmacology*
  • Rifampin / therapeutic use
  • Tuberculosis, Pulmonary / drug therapy
  • gamma-Glutamyltransferase / blood


  • Hydroxycholecalciferols
  • Parathyroid Hormone
  • gamma-Glutamyltransferase
  • Alkaline Phosphatase
  • Calcitriol
  • Isoniazid
  • Rifampin