Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency

François Robert

doi:10.1016/j.molcel.2017.10.005

Spt6 Gets in the Way of Polycomb to Promote ESC Pluripotency

Mol Cell. 2017 Oct 19;68(2):263-264. doi: 10.1016/j.molcel.2017.10.005.

Author

François Robert¹

Affiliation

¹ Institut de recherches cliniques de Montréal, 110 Avenue des Pins Ouest, Montréal, QC, Canada; Département de Médecine, Faculté de Médecine, Université de Montréal, 2900 Boulevard Édouard-Montpetit, Montréal, QC, Canada. Electronic address: francois.robert@ircm.qc.ca.

PMID: 29053954
DOI: 10.1016/j.molcel.2017.10.005

Abstract

Despite expressing high levels of Polycomb group proteins, embryonic stem cells (ESCs) are refractory to H3K27 trimethylation, notably at super-enhancers regulating key pluripotency genes. In this issue of Molecular Cell, Wang et al. (2017) report that the histone chaperone Spt6 prevents H3K27 trimethylation of key ESC super-enhancers.

Publication types

Comment

MeSH terms

Cell Line
Drosophila Proteins*
Histones
Peptide Elongation Factors*
Polycomb-Group Proteins

Substances

Drosophila Proteins
Histones
Peptide Elongation Factors
Polycomb-Group Proteins