Diagnosis of Kawasaki disease

Int J Rheum Dis. 2018 Jan;21(1):36-44. doi: 10.1111/1756-185X.13224. Epub 2017 Nov 13.


Kawasaki disease (KD) is a medium vessel vasculitis with predilection for coronary arteries. Due to lack of a reliable confirmatory laboratory test, the diagnosis of KD is based on a constellation of clinical findings that appear in a typical temporal sequence. These diagnostic criteria have been modified from time to time and the most recent guidelines have been proposed by the American Heart Association (AHA) in 2017. However, several children may have incomplete or atypical forms of KD and the diagnosis can often be difficult, especially in infants and young children. In this review, we have detailed the steps involved in arriving at a diagnosis of KD and also highlight the important role of echocardiography in diagnosis and management of children with KD.

Keywords: AHA; Kawasaki disease; diagnosis; echocardiography.

Publication types

  • Review

MeSH terms

  • Age of Onset
  • Algorithms
  • Biomarkers / blood
  • Child
  • Child, Preschool
  • Coronary Vessels / diagnostic imaging*
  • Coronary Vessels / pathology
  • Decision Support Techniques
  • Developing Countries
  • Echocardiography*
  • Humans
  • Infant
  • Mucocutaneous Lymph Node Syndrome / blood
  • Mucocutaneous Lymph Node Syndrome / complications
  • Mucocutaneous Lymph Node Syndrome / diagnostic imaging*
  • Mucocutaneous Lymph Node Syndrome / pathology
  • Practice Guidelines as Topic
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors


  • Biomarkers