The Use of Decellularized Human Placenta in Full-Thickness Wound Repair and Periarticular Soft Tissue Reconstruction: An Update on Regenerative Healing

Clin Podiatr Med Surg. 2018 Jan;35(1):95-104. doi: 10.1016/j.cpm.2017.08.010. Epub 2017 Oct 23.


Prolonged or incomplete healing of the foot and ankle can pose significant challenges. Therefore, investigators have begun searching for alternative treatment strategies. With advances in tissue engineering, decellularized human placental connective tissue matrix has been suggested as a means to achieve more rapid and complete healing for various soft tissue and bone procedures. Basic science and clinical studies have shown that decellularized human placental connective tissue matrix can support regenerative healing through cellular migration, accelerated tissue remodeling, and the establishment of functional tissue. Additional research is needed to fully explore and evaluate clinical applications within the foot and ankle.

Keywords: Amniotic membrane; Extracellular matrix; Growth factors; Placenta; Regenerative healing.

Publication types

  • Review

MeSH terms

  • Ankle Injuries / surgery*
  • Female
  • Foot Injuries / surgery*
  • Humans
  • Placenta / physiology*
  • Pregnancy
  • Regeneration / physiology
  • Soft Tissue Injuries / surgery*
  • Tissue Engineering
  • Tissue Scaffolds
  • Wound Healing / physiology*
  • Wounds and Injuries / physiopathology
  • Wounds and Injuries / surgery