Hypercalcemia-Induced Pancreatitis in Pregnancy Following Calcium Carbonate Ingestion

J Pharm Pract. 2019 Apr;32(2):225-227. doi: 10.1177/0897190017745410. Epub 2017 Dec 14.


Background: Calcium carbonate is often used to relieve Gastroesophageal Reflux Disease (GERD) in pregnant patients. This report describes a potentially serious complication.

Case: A pregnant female presented at 34 weeks gestation with abdominal pain, nausea, and vomiting. Home medications included an unquantifiable amount of calcium carbonate 500 mg due to constant consumption for GERD. Laboratory findings included elevated calcium, amylase, lipase, and triglyceride level. Pancreatitis was diagnosed and abdominal ultrasound excluded gallstones. Despite hydration, lipase rose and emergency cesarean section was performed. Hypercalcemia was managed by intravenous fluid administration. After delivery, pancreatitis resolved.

Conclusion: Pancreatitis developed in pregnant patient with hypercalcemia due to excessive calcium carbonate ingestion and resolved after delivery of the fetus, fluid resuscitation, and return of calcium level to normal.

Keywords: calcium carbonate; hypercalcemia; pancreatitis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Calcium Carbonate / adverse effects*
  • Cesarean Section
  • Female
  • Gastroesophageal Reflux / drug therapy
  • Humans
  • Hypercalcemia / chemically induced*
  • Pancreatitis / blood*
  • Pancreatitis / chemically induced*
  • Pregnancy
  • Pregnancy Complications / blood*
  • Pregnancy Complications / chemically induced*


  • Calcium Carbonate