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Randomized Controlled Trial
. 2018 Jun;43(6):565-570.
doi: 10.1139/apnm-2017-0521. Epub 2018 Jan 9.

Magnesium-zinc-calcium-vitamin D Co-Supplementation Improves Glycemic Control and Markers of Cardiometabolic Risk in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

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Randomized Controlled Trial

Magnesium-zinc-calcium-vitamin D Co-Supplementation Improves Glycemic Control and Markers of Cardiometabolic Risk in Gestational Diabetes: A Randomized, Double-Blind, Placebo-Controlled Trial

Maryam Karamali et al. Appl Physiol Nutr Metab. .

Abstract

To the best our knowledge, data on the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk in gestational diabetes mellitus (GDM) are scarce. The purpose of this study was to establish the effects of magnesium-zinc-calcium-vitamin D co-supplementation on glycemic control and markers of cardiometabolic risk of GDM patients. Sixty patients with GDM, aged 18-40 years, were randomized into 2 groups to intake either magnesium-zinc-calcium-vitamin D co-supplements or placebo (n = 30 each group) for 6 weeks in a randomized, double-blind, placebo-controlled trial. Fasting blood samples were taken at baseline and week 6 to quantify related markers. After the 6-week intervention, compared with the placebo, magnesium-zinc-calcium-vitamin D co-supplementation resulted in significant reductions in fasting plasma glucose (-0.37 ± 0.09 vs. +0.01 ± 0.09 mmol/L, P = 0.003), serum insulin levels (-21.0 ± 4.8 vs. +7.2 ± 4.8 pmol/L, P < 0.001), homeostatic model of assessment for insulin resistance (-1.0 ± 1.1 vs. +0.3 ± 1.3, P < 0.001), and a significant increase in quantitative insulin sensitivity check index (+0.02 ± 0.03 vs. -0.002 ± 0.03, P = 0.003). In addition, magnesium-zinc-calcium-vitamin D co-supplementation significantly decreased serum triglycerides (-0.25 ± 0.10 vs. +0.34 ± 0.10 mmol/L, P = 0.001) and very-low-density-cholesterol concentrations (-0.11 ± 0.04 vs. +0.15 ± 0.04 mmol/L, P = 0.001) compared with the placebo. Overall, the results of this study demonstrated that magnesium-zinc-calcium-vitamin D co-supplementation for 6 weeks among patients with GDM had beneficial effects on glycemic control and few markers of cardiometabolic risk.

Keywords: cardiometabolic risk; contrôle glycémique; diabète gestationnel; gestational diabetes mellitus; glycemic control; risque cardiométabolique; supplementation; supplémentation.

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