Conserved Functional Dynamics: I Like to Move It, Move It!

Vladimir N Uversky

doi:10.1016/j.str.2018.02.010

Conserved Functional Dynamics: I Like to Move It, Move It!

Structure. 2018 Mar 6;26(3):371-373. doi: 10.1016/j.str.2018.02.010.

Author

Vladimir N Uversky¹

Affiliation

¹ Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA; Institute for Biological Instrumentation, Russian Academy of Sciences, 142290 Pushchino, Moscow Region, Russia. Electronic address: vuversky@health.usf.edu.

PMID: 29514077
DOI: 10.1016/j.str.2018.02.010

Abstract

The catalytic activities of enzymes are typically associated with their unique structures. However, structural dynamics may also play a functional role in enzyme catalysis. In support of this idea, Narayanan et al. (2018) show in this issue of Structure that enzymes are characterized by the presence of evolutionarily conserved dynamic traits.

Publication types

Comment

MeSH terms

Biological Evolution*
Catalysis
Enzymes* / metabolism

Substances

Enzymes