90 years of monoamine oxidase: some progress and some confusion

J Neural Transm (Vienna). 2018 Nov;125(11):1519-1551. doi: 10.1007/s00702-018-1881-5. Epub 2018 Apr 10.


It would not be practical to attempt to deal with all the advances that have informed our understanding of the behavior and functions of this enzyme over the past 90 years. This account concentrates key advances that explain why the monoamine oxidases remain of pharmacological and biochemical interest and on some areas of continuing uncertainty. Some issues that remain to be understood or are in need of further clarification are highlighted.

Keywords: Aldehydes; Ammonia; Cyclopropylamines; Depression; Hydrazines; Hydrogen peroxide; Imidazolines; Inhibitors; Kinetics, suicide substrates; Monoamine oxidase reaction; Parkinson’s disease; Propargylamines.

Publication types

  • Historical Article
  • Review

MeSH terms

  • Animals
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Monoamine Oxidase / history*
  • Monoamine Oxidase / physiology*
  • Neurology / history


  • Monoamine Oxidase