Psychopharmacology and Cardiovascular Disease

J Am Coll Cardiol. 2018 May 22;71(20):2346-2359. doi: 10.1016/j.jacc.2018.03.458.


This review discusses common mental health disorders and their associations with cardiovascular disease risks. Commonly found mental health disorders include depression, anxiety, and personality types. The link between depression and cardiovascular disease mortality has been established. Depression is also common in patients with heart failure. In addition to discussing psychological disorders, a review of psychotropic drugs is also included. Drugs are described for therapy for depression and anxiety, as well as associations with cardiovascular drug-drug interactions. Drug-drug interactions are more common and potentially dangerous in elderly patients, in whom the conditions often coexist. The most common drug-drug interactions involve the P450 system of enzymes.

Keywords: drug-drug interactions; psychiatric disorders; psychopharmacology.

Publication types

  • Review

MeSH terms

  • Cardiovascular Agents / administration & dosage*
  • Cardiovascular Agents / pharmacokinetics
  • Cardiovascular Diseases / diagnosis
  • Cardiovascular Diseases / drug therapy*
  • Cardiovascular Diseases / epidemiology*
  • Drug Interactions / physiology
  • Humans
  • Mental Disorders / diagnosis
  • Mental Disorders / drug therapy*
  • Mental Disorders / epidemiology*
  • Psychopharmacology
  • Psychotropic Drugs / administration & dosage*
  • Psychotropic Drugs / pharmacokinetics
  • Risk Factors


  • Cardiovascular Agents
  • Psychotropic Drugs