mTOR'ing across the Cortex by Chopping the Cilia

Neuron. 2018 Jul 11;99(1):3-5. doi: 10.1016/j.neuron.2018.06.042.


Somatic mutation of the MTOR gene is a genetic etiology of focal malformations of cortical development. In this issue of Neuron, Park et al. (2018) identify defective autophagy-dependent ciliogenesis/Wnt signaling as an underlying mechanism affecting neuronal migration and cortical lamination.

Publication types

  • Comment

MeSH terms

  • Brain
  • Cilia*
  • Mutation
  • Neurons
  • TOR Serine-Threonine Kinases / genetics*


  • TOR Serine-Threonine Kinases