Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study

Med Oncol Tumor Pharmacother. 1986;3(1):39-42. doi: 10.1007/BF02934575.


Thirty-two patients were entered into a double blind trial of antiemetic support in patients being treated with cisplatin. Patients were allocated to receive either oral nabilone (1 mg 8 hourly) or intravenous metoclopramide (1 mg kg-1 3 hourly) in random order over 4 courses. There was no difference between the two treatments in the overall incidence or severity of vomiting, although a subgroup of patients enjoyed a substantial reduction in episodes of vomiting whilst receiving metoclopramide. Side-effects were predictable from the pharmacology of the drugs.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Antiemetics* / adverse effects
  • Cisplatin / adverse effects*
  • Double-Blind Method
  • Dronabinol / analogs & derivatives*
  • Dronabinol / therapeutic use
  • Humans
  • Metoclopramide / therapeutic use*
  • Nausea / chemically induced*


  • Antiemetics
  • nabilone
  • Dronabinol
  • Metoclopramide
  • Cisplatin