Subcutaneous panniculitis-like T-cell lymphoma responsive to combination therapy with methotrexate and corticosteroids

Dermatol Online J. 2018 Sep 15;24(9):13030/qt8fk9n58w.


Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare condition that falls underneath the umbrella of primary cutaneous T-cell lymphomas (CTCLs). SPTCL can be very difficult to diagnose as it may mimic other subtypes of CTCL, such as γ/δ T-cell lymphoma (TCL), or other forms of panniculitis. Confirmation of diagnosis often requires immunohistochemical analysis and is essential for proper prognosis and therapeutic management. Herein, we present a case of SPTCL that mimicked lupus panniculitis and was successfully treated with prednisone taper and methotrexate.

Publication types

  • Case Reports

MeSH terms

  • Anti-Inflammatory Agents / therapeutic use
  • Dermatologic Agents / therapeutic use*
  • Diagnosis, Differential
  • Female
  • Humans
  • Immunosuppressive Agents / therapeutic use
  • Lymphoma, T-Cell / diagnosis
  • Lymphoma, T-Cell / drug therapy*
  • Methotrexate / therapeutic use*
  • Middle Aged
  • Panniculitis / diagnosis
  • Panniculitis / drug therapy*
  • Panniculitis, Lupus Erythematosus / diagnosis*
  • Prednisone / therapeutic use*


  • Anti-Inflammatory Agents
  • Dermatologic Agents
  • Immunosuppressive Agents
  • Prednisone
  • Methotrexate

Supplementary concepts

  • Subcutaneous panniculitis-like T-cell lymphoma