Syndrome of inappropriate antidiuresis in Waldenström's macroglobulinemia

Am J Med. 1986 Jun;80(6):1242-4. doi: 10.1016/0002-9343(86)90696-0.


Hyponatremia due to the syndrome of inappropriate antidiuresis rather than due to isotonic hyponatremia from hyperproteinemia developed in a patient with Waldenström's macroglobulinemia. The patient was unable to excrete a water load normally despite suppression of antidiuretic hormone to normal levels. The temporal relationship between control of the tumor and resolution of the hyponatremia suggests that the tumor either produced a substance that enhanced the hydro-osmotic effect of endogenous antidiuretic hormone or produced an antidiuretic substance immunologically different from antidiuretic hormone. The syndrome of inappropriate antidiuresis should be suspected in hyponatremic patients with Waldenström's macroglobulinemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Arginine Vasopressin / blood
  • Diuresis
  • Humans
  • Hyponatremia / complications*
  • Hyponatremia / physiopathology
  • Male
  • Waldenstrom Macroglobulinemia / complications*
  • Water-Electrolyte Balance


  • Arginine Vasopressin