Diabetic cardiomyopathy - A comprehensive updated review

Prog Cardiovasc Dis. 2019 Jul-Aug;62(4):315-326. doi: 10.1016/j.pcad.2019.03.003. Epub 2019 Mar 25.


Diabetes causes cardiomyopathy and increases the risk of heart failure independent of hypertension and coronary heart disease. This condition called "Diabetic Cardiomyopathy" (DCM) is becoming a well- known clinical entity. Recently, there has been substantial research exploring its molecular mechanisms, structural and functional changes, and possible development of therapeutic approaches for the prevention and treatment of DCM. This review summarizes the recent advancements to better understand fundamental molecular abnormalities that promote this cardiomyopathy and novel therapies for future research. Additionally, different diagnostic modalities, up to date screening tests to guide clinicians with early diagnosis and available current treatment options has been outlined.

Keywords: Cardiomyopathy; Diabetes; Diastolic dysfunction; Ejection fraction; Heart failure; Risk factors.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood
  • Cardiac Imaging Techniques / methods
  • Comorbidity
  • Diabetes Mellitus / diagnosis
  • Diabetes Mellitus / epidemiology*
  • Diabetes Mellitus / therapy
  • Diabetic Cardiomyopathies / diagnostic imaging
  • Diabetic Cardiomyopathies / epidemiology*
  • Diabetic Cardiomyopathies / therapy
  • Early Diagnosis
  • Female
  • Heart Failure / diagnostic imaging
  • Heart Failure / epidemiology*
  • Heart Failure / therapy
  • Humans
  • Male
  • Mass Screening / methods*
  • Prognosis
  • Risk Assessment
  • Survival Analysis


  • Biomarkers