The L-Type Amino Acid Transporter LAT1-An Emerging Target in Cancer

Int J Mol Sci. 2019 May 16;20(10):2428. doi: 10.3390/ijms20102428.


Chronic proliferation is a major hallmark of tumor cells. Rapidly proliferating cancer cells are highly dependent on nutrients in order to duplicate their cell mass during each cell division. In particular, essential amino acids are indispensable for proliferating cancer cells. Their uptake across the cell membrane is tightly controlled by membrane transporters. Among those, the L-type amino acid transporter LAT1 (SLC7A5) has been repeatedly found overexpressed in a vast variety of cancers. In this review, we summarize the most recent advances in our understanding of the role of LAT1 in cancer and highlight preclinical studies and drug developments underlying the potential of LAT1 as therapeutic target.

Keywords: cancer; inhibitor; l-type amino acid transporter LAT1; preclinical studies; targeted therapy.

Publication types

  • Review

MeSH terms

  • Amino Acid Transport System y+L
  • Amino Acids / metabolism*
  • Biological Transport
  • Cell Proliferation
  • Drug Discovery
  • Humans
  • Large Neutral Amino Acid-Transporter 1 / drug effects
  • Large Neutral Amino Acid-Transporter 1 / metabolism*
  • Nanoparticles / chemistry
  • Neoplasm Proteins
  • Neoplasms / metabolism*


  • Amino Acid Transport System y+L
  • Amino Acids
  • Large Neutral Amino Acid-Transporter 1
  • Neoplasm Proteins
  • SLC43A1 protein, human