Beginning of a New Era: Mapping the Bone Marrow Niche

Ayako Nakamura-Ishizu; Ben D MacArthur; Toshio Suda

doi:10.1016/j.cell.2019.05.042

Beginning of a New Era: Mapping the Bone Marrow Niche

Cell. 2019 Jun 13;177(7):1679-1681. doi: 10.1016/j.cell.2019.05.042.

Authors

Ayako Nakamura-Ishizu¹, Ben D MacArthur², Toshio Suda³

Affiliations

¹ Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan.
² International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan; Mathematical Sciences, University of Southampton, Southampton SO17 1BJ, UK; Centre for Human Development Stem Cells and Regeneration, Faculty of Medicine, University of Southampton, Southampton SO17 1BJ, UK.
³ Cancer Science Institute, National University of Singapore, 14 Medical Drive, MD6, 117599, Singapore; International Research Center for Medical Sciences, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto City 860-0811, Japan. Electronic address: sudato@keio.jp.

PMID: 31199915
DOI: 10.1016/j.cell.2019.05.042

Abstract

Baryawno et al. provide a comprehensive atlas of the mouse bone marrow stroma based on single-cell RNA-sequencing data. Their analysis reveals a taxonomy of 17 distinct cell types with diverse functions that highlights the complexity of the bone marrow stroma and paves the way for future in vivo assessment.

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MeSH terms

Animals
Bone Marrow Cells
Bone Marrow*
Homeostasis
Leukemia*
Mice
Sequence Analysis, RNA