Lynch Syndrome in Urologic Malignancies - What Does the Urologist Need to Know?

Hanan Goldberg; Christopher J D Wallis; Zachary Klaassen; Thenappan Chandrasekar; Neil Fleshner; Alexandre R Zlotta

doi:10.1016/j.urology.2019.07.004

Lynch Syndrome in Urologic Malignancies - What Does the Urologist Need to Know?

Urology. 2019 Dec:134:24-31. doi: 10.1016/j.urology.2019.07.004. Epub 2019 Jul 11.

Authors

Hanan Goldberg¹, Christopher J D Wallis², Zachary Klaassen², Thenappan Chandrasekar², Neil Fleshner², Alexandre R Zlotta³

Affiliations

¹ Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario, Canada. Electronic address: gohanan@gmail.com.
² Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario, Canada.
³ Division of Urology, Department of Surgical Oncology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Urology, Department of Surgery, Sinai Health System, Toronto, Ontario, Canada.

PMID: 31302137
DOI: 10.1016/j.urology.2019.07.004

Abstract

Lynch Syndrome (LS) entails a defective DNA mismatch repair system, which is the postreplicative proofreading and editing system, ensuring our genome's integrity. LS predisposes to several cancers, most commonly colorectal and endometrial cancers. LS occurs in approximately 1 in 250-1000 people. LS is associated with urological malignancies with upper tract urothelial carcinoma the most common, although still clinically underestimated. Other urologic malignancies possibly associated with LS include bladder, prostate, testis, and renal cell carcinoma. Ascertaining their true prevalence in LS is mandatory for their and their relatives' diagnosis and treatment. Awareness regarding identifying patients at risk for LS through assessment of personal and familial oncologic history is critical among urologists.

Publication types

Review

MeSH terms

Colorectal Neoplasms, Hereditary Nonpolyposis* / genetics
Colorectal Neoplasms, Hereditary Nonpolyposis* / therapy
DNA Mismatch Repair / genetics
Humans
Patient Care Management
Risk Assessment
Urogenital Neoplasms* / genetics
Urogenital Neoplasms* / pathology
Urogenital Neoplasms* / therapy