IgG4 hypophysitis: Diagnosis and management

M Lojou; J F Bonneville; M Ebbo; N Schleinitz; F Castinetti

doi:10.1016/j.lpm.2020.104016

IgG4 hypophysitis: Diagnosis and management

Presse Med. 2020 Apr;49(1):104016. doi: 10.1016/j.lpm.2020.104016. Epub 2020 Mar 29.

Authors

M Lojou¹, J F Bonneville², M Ebbo³, N Schleinitz³, F Castinetti⁴

Affiliations

¹ Inserm, U1251, CRMR HYPO, department of endocrinology, Aix-Marseille université, La Conception hospital, AP-HM, 147, boulevard Baille, Marseille, France.
² Departments of endocrinology and medical imaging, centre hospitalier universitaire de Liège, Liège, Belgium.
³ Département de médecine interne, Timone, Aix-Marseille université, AP-HM, 13005 Marseille, France.
⁴ Inserm, U1251, CRMR HYPO, department of endocrinology, Aix-Marseille université, La Conception hospital, AP-HM, 147, boulevard Baille, Marseille, France. Electronic address: Frederic.castinetti@ap-hm.fr.

PMID: 32234384
DOI: 10.1016/j.lpm.2020.104016

Abstract

IgG4-related hypophysitis is a rare disease, due to a lymphoplasmocytic IgG4 positive infiltration of the pituitary. Literature data are scarce, even though the description of cases has drastically increased over the last years. The aim of this review is to better characterize the natural history, the diagnosis and the management of IgG4-related hypophysitis, based on a clinical case, an exhaustive Pubmed research, and a reappraisal of the criteria for diagnosis. We will specifically focus on the differences with other etiologies of hypophysitis, in the aim of improving the diagnostic procedures for all the physicians who could have to take care of such patients.

Publication types

Case Reports
Review

MeSH terms

Adult
Autoimmune Hypophysitis / diagnosis*
Autoimmune Hypophysitis / etiology
Autoimmune Hypophysitis / therapy
Female
Humans
Immunoglobulin G4-Related Disease / diagnosis*
Immunoglobulin G4-Related Disease / therapy
Magnetic Resonance Imaging
Male
Middle Aged
Symptom Assessment