New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine

Eleonora Colombo; Laura Polito; Michele Biocotino; Paola Marzullo; Mariafrancesca Hyeraci; Lisa Dalla Via; Daniele Passarella

doi:10.1021/acsmedchemlett.9b00668

New Class of Betulinic Acid-Based Nanoassemblies of Cabazitaxel, Podophyllotoxin, and Thiocolchicine

ACS Med Chem Lett. 2020 Feb 28;11(5):895-898. doi: 10.1021/acsmedchemlett.9b00668. eCollection 2020 May 14.

Authors

Eleonora Colombo¹, Laura Polito², Michele Biocotino¹, Paola Marzullo¹, Mariafrancesca Hyeraci³, Lisa Dalla Via³, Daniele Passarella¹

Affiliations

¹ Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133 Milano, Italy.
² CNR-ISTM, Via G. Fantoli 16/15, 20138 Milano, Italy.
³ Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, Via F. Marzolo 5, 35131 Padova, Italy.

Abstract

Betulinic acid is validated as a new self-assembly inducer for the formation of nanoparticles (NPs) in combination with different drugs. The target compounds are characterized by the presence of anticancer drugs acting on tubulin dynamics and of a linker that could be a carbon chain or a triazole-based one. Nanoparticles formed are characterized and their biological activity is evaluated.