Microfluidic synthesis has attracted extensive attention due to the ability for the multistep precise control of the synthesis parameters, continuous and reproducible preparation, and its ease of integration. However, its commercial application is still affected by its low production efficiency. In this case, we report a high-throughput continuous flow synthesis of highly dispersed PtFeCu/C nanocatalysts using a metal microchip setup with four parallel channels. The high flow rate and integrated channels enabled improving the throughput, whereby 1.33 g h-1 of catalysts could be achieved with the flow rate of 1200 mL h-1 under the experimental conditions. The as-prepared PtFeCu/C exhibited excellent performance, 1.94 times higher than Pt/C for methanol oxidation. More importantly, the yield of the PtFeCu/C nanocatalysts could be further increased through designing numerous parallel channels, which might provide a promising approach for large-scale commercialization of the catalysts. Such a high-throughput fabrication pathway is significant for the large-scale industrial production of nanomaterials.