Acute kidney damage by PM2.5 exposure in a rat model

Environ Toxicol Pharmacol. 2021 Apr:83:103587. doi: 10.1016/j.etap.2021.103587. Epub 2021 Jan 15.


PM2.5 exposure is associated with a glomerular filtration rate (GFR) reduction, and renal tissue damage. The goal of this study was demonstrate the acute effect of PM2.5 on the kidney. Male rats were acutely exposed to PM2.5 or filtered air. Blood pressure was mesure and early kidney biomarkers were evaluated in serum and urine samples, and also IL-1β, IL-6 and TNFα were determined. Oxidative biomarkers, angiotensin/bradykinin-related proteins, KIM-1, IL-6 and histology were determined. Blood pressure, GFR, and early kidney damage biomarkers increase together with oxidative biomarkers and angiotensin/bradykinin endocrine-related proteins increased after exposure to PM2.5. Urinary IL-6 increased after exposure to PM2.5, whereas in kidney cortex decreased. Histological changes were observed and accompanied by the induction of KIM-1. Acute exposure to PM2.5 not decline kidney function. However, it can induce early kidney damage biomarkers, oxidative stress, inflammation and angiotensin mediators, which perhabs culminates in a lose of renal function.

Keywords: Acute exposure; Kidney damage; Oxidative stress; PM(2.5).

MeSH terms

  • Air Pollutants / toxicity*
  • Animals
  • Blood Pressure / drug effects
  • Cytokines / immunology
  • Cytokines / urine
  • Inflammation / etiology
  • Inflammation / immunology
  • Inflammation / pathology
  • Inflammation / physiopathology
  • Kidney / drug effects*
  • Kidney / pathology
  • Kidney / physiology
  • Kidney Diseases / etiology*
  • Kidney Diseases / pathology
  • Kidney Diseases / physiopathology
  • Kidney Diseases / urine
  • Lung / drug effects
  • Lung / immunology
  • Lung / pathology
  • Male
  • Particulate Matter / toxicity*
  • Rats
  • Rats, Sprague-Dawley


  • Air Pollutants
  • Cytokines
  • Particulate Matter