In situ drug release measuring in α-TCP cement by electrochemical impedance spectroscopy

J Mater Sci Mater Med. 2021 Apr 1;32(4):38. doi: 10.1007/s10856-021-06507-9.

Abstract

The use of drug delivery systems is a good technique to leave the right quantity of medicine in the patient's body in a suitable dose, because the drug application is delivered directly to the affected region. The current techniques such as HPLC and UV-Vis for the drug delivery calculation has some disadvantages, as the accuracy and the loss of the sample after characterization. With the aim of reducing the amount of material used during the characterization and have a non-destructive test with instantaneous results, the present paper shows the possibility of using electrochemical impedance spectroscopy (EIS) to have a drug delivery measurement during the release phenomena for a calcium phosphate cement (CFC) delivery system with gentamicin sulfate (GS) and lidocaine hydrochloride (LH), at a ratio of 1% and 2%, respectively. The equivalent circuit and the chemical mechanism involved during the measurements have been proposed as a tool to determine the drug delivery profile. The method has been compared with the UV-Vis technique. XRD was realized to verify conditions, before and after release. It was possible to verify the potential for using EIS as an instant technique to quantify drug delivery.

MeSH terms

  • Anti-Bacterial Agents / administration & dosage
  • Bone Cements / chemistry
  • Calcium Phosphates / chemistry
  • Chromatography, High Pressure Liquid
  • Dental Materials
  • Dielectric Spectroscopy
  • Drug Delivery Systems*
  • Drug Liberation
  • Electric Impedance
  • Electrochemistry / methods*
  • Electrolytes
  • Equipment Design
  • Gentamicins / chemistry
  • Glass Ionomer Cements
  • Humans
  • Kinetics
  • Lidocaine / chemistry
  • Models, Theoretical
  • Spectrophotometry
  • Spectrophotometry, Ultraviolet
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Bone Cements
  • Calcium Phosphates
  • Dental Materials
  • Electrolytes
  • Gentamicins
  • Glass Ionomer Cements
  • alpha-tricalcium phosphate
  • calcium phosphate
  • Lidocaine